Pathology & LaboratoryStatus I

CPT Code 80350

Drug test for synthetic cannabinoids, 1 to 3 drug classes

Source: CMS 2026 Physician Fee ScheduleEffective Reviewed by the D3rx Clinical Billing Team

2026 Medicare pricing

CPT 80350 is not priced under the Medicare Physician Fee Schedule (status I). Laboratory tests are reimbursed under the Clinical Laboratory Fee Schedule (CLFS), not the PFS.

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Common ICD-10 diagnoses billed with 80350

Diagnoses frequently paired with 80350 on claims. A relevant diagnosis helps support medical necessity, but it does not by itself guarantee payment. Documentation, the service performed, and payer/CMS policy all apply. Link each line item to the diagnosis that best documents why the service was needed.

  • E78.0Metabolic condition 0 for 80350
  • E78.1Metabolic condition 1 for 80350
  • E78.2Metabolic condition 2 for 80350
  • E78.3Metabolic condition 3 for 80350
  • E78.4Metabolic condition 4 for 80350
  • E78.5Metabolic condition 5 for 80350
  • E78.6Metabolic condition 6 for 80350
  • E78.7Metabolic condition 7 for 80350

Laboratory pricing note

Clinical laboratory tests like 80350 are generally reimbursed under the Medicare Clinical Laboratory Fee Schedule (CLFS), which sets a national limitation amount per test rather than RVU-based PFS pricing. Bill the test on a CMS-1500/837P with the ordering diagnosis; payment follows the CLFS amount for the date of service.

Related Pathology & Laboratory codes

8005383036850258006188305803078230681003

Related guides

Medical billing disclaimer

Rates shown are 2026 Physician Fee Schedule amounts and are for educational reference. Commercial payers, locality, and plan rules vary. Always verify current rates and coverage with the payer before billing. D3rx is not responsible for claim outcomes.